Small molecule drugs bind to a pocket in disease-causing target proteins based on complementarity in shape and physicochemical properties. This approach has been successful in treating various diseases. However, there is a likelihood that other proteins could have binding pockets that are complementary to small molecules, leading to potential new therapeutic targets. The discovery of these putative protein targets could revolutionize the field of drug development and provide new avenues for treating diseases. Furthermore, understanding the mechanisms by which small molecules interact with proteins could lead to the design of more effective and targeted therapies.