The substitution mechanism of Au in In- and Fe-bearing minerals is a crucial aspect of understanding the geochemical behavior of gold in various geological settings. The study of this mechanism is essential for predicting the distribution and concentration of gold in different types of rocks and minerals. The research aims to investigate the substitution of Au in In- and Fe-bearing minerals, including sphalerite, and to determine the factors that control this process. The results of this study will provide valuable insights into the geochemical behavior of gold and its potential applications in the field of mineral exploration and extraction.