Dendritic cells (DCs) are key in the initiation of the adaptive T cell responses to tailor adequate immunity that corresponds to the type of pathogen. They are capable of recognizing and processing antigens, and presenting them to T cells to induce an immune response. The process of antigen presentation is crucial for the development of an effective immune response. In this context, the binding and uptake of α2-3 sialic acid by human monocytic cells is an important step in the recognition and processing of antigens. This process is essential for the initiation of an immune response against pathogens that express α2-3 sialic acid on their surface. The binding and uptake of α2-3 sialic acid by human monocytic cells is a critical step in the recognition and processing of antigens, and is essential for the initiation of an immune response against pathogens that express α2-3 sialic acid on their surface.