Antibiotic-associated disruption of microbiota composition has been a long-standing concern in the field of microbiology. The use of antibiotics can lead to a significant alteration in the balance of the gut microbiota, resulting in a range of negative consequences, including the development of antibiotic-associated diarrhea and the disruption of the gut barrier function. Furthermore, the disruption of the gut microbiota can also lead to changes in the host's immune system, making it more susceptible to infections. The implementation of strategies to prevent or mitigate the disruption of the gut microbiota is crucial in maintaining a healthy gut microbiome and preventing the development of antibiotic-associated complications.