This research activity aims to investigate the relationship between severe symptoms and salivary interleukin-6 levels. The study will involve collecting saliva samples from patients with severe symptoms and analyzing them for interleukin-6 levels. The findings of this study will provide valuable insights into the underlying mechanisms of severe symptoms and potential therapeutic targets. Furthermore, this research will contribute to the development of novel diagnostic tools for identifying patients at risk of severe symptoms. By exploring the link between severe symptoms and salivary interleukin-6, this study will shed light on the complex interactions between the immune system and the nervous system, ultimately leading to improved patient outcomes.