Found an issue? Give us feedback

https://explore.open...arrow_drop_down

https://explore.openaire.eu/se...

Research Activity

Select content type to embed

All Research products

arrow_drop_down

<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

QSAR modeling and structure based virtual screening

appsOther research productkeyboard_double_arrow_right Research Activity 01 Oct 2012

QSAR modeling and structure based virtual screening

- Summary
- Metrics

Abstract

Phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) kinases belong to the phosphatidylinositol-3-kinase-related kinase (PIKK) family of kinases. Dysregulation of PI3K/mTOR signaling pathways is associated with various diseases, including cancer, diabetes, and cardiovascular diseases. This research activity aims to develop a QSAR model for predicting the activity of PI3K/mTOR inhibitors using structure-based virtual screening. The model will be trained on a dataset of known PI3K/mTOR inhibitors and validated using a separate test set. The results will be used to identify potential lead compounds for further optimization and development as therapeutic agents.

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

Found an issue? Give us feedback

Average

Related to Research communities

Cancer Research