Histotripsy is a non-thermal, non-invasive focused ultrasound therapy using cavitation to ablate tissue. This therapy has been explored for various applications, including the treatment of osteosarcoma. The ablation effects of histotripsy are characterized by the formation of cavitation bubbles, which can lead to tissue damage. The goal of this research activity is to investigate the ablation effects of histotripsy and to develop a better understanding of its mechanisms. This will involve the use of computational models and experimental techniques to study the behavior of cavitation bubbles and their impact on tissue. The results of this research will have important implications for the development of new treatments for osteosarcoma and other diseases.