Canine adenovirus type 1 (CAdV-1) is the aetiological agent of infectious canine hepatitis (ICH) in domestic dogs (Canis familiaris). In spite of the widespread use of vaccination, CAdV-1 continues to pose a significant threat to canine health. The virus has a unique genetic feature that allows it to evade the host's immune system, making it a challenging pathogen to combat. This study aims to investigate the genetic characteristics of CAdV-1 and its implications for the development of effective vaccines and treatments.