The transcription factor Tbx15 plays a crucial role in the differentiation of brown adipose tissue. Its expression is predominantly found in this tissue and in certain white adipose depots that can give rise to brown-in-white (“brite”/“beige”) adipocytes. This suggests that Tbx15 is essential for the development of thermogenic adipocytes, which are capable of producing heat. The study of Tbx15 and its role in brown adipose tissue differentiation can provide valuable insights into the mechanisms underlying thermogenesis and obesity.