TNF microsatellites polymorphism is associated with rheumatoid arthritis. Confirming evidence in northwestern Colombians.
Copyright policy )TNF microsatellites polymorphism is associated with rheumatoid arthritis. Confirming evidence in northwestern Colombians.
To examine the contribution of tumor necrosis factor alpha (TNF) microsatellite (a to e) polymorphism to the genetic risk of developing rheumatoid arthritis (RA) in a northwestern Colombian population.This was an association study in which 108 RA patients and 222 matched individuals were enrolled. HLA-DRB1 and DQB1 polymorphisms were evaluated to examine for linkage disequilibrium between these loci and TNF micro- satellites. Genotyping was performed using denaturing polyacrylamide gels and polymerase chain reaction-sequence techniques.By unconditional logistic regression analysis, the TNFa6 allele (OR=2.37, 95%CI 1.07-5.24) and the TNFb4 allele (OR=3.01, 95%CI 1.07-9.00) were observed to be associated with disease. These associations were independent of HLA-DR and HLA-DQ since linkage disequilibrium between HLA class II and TNF microsatellites was not observed. In addition, patients with the TNFa8 allele had a five times greater risk of developing extra-articular manifestations as compared to patients without this allele (OR=5.07, 95%CI 1.14-22.52), regardless of age and the duration of disease. Haplotype analysis disclosed a protective effect for TNFa7/b7/c1/d4/e3/-308G/-238G.These results confirm that the TNF locus exerts a primary influence on both susceptibility to and the severity of RA.
Male, Unclassified drug, Protein function, Tnf, Hla antigen class 2, Gene sequence, Gene locus, Severity of Illness Index, Linkage Disequilibrium, Arthritis, Rheumatoid, Risk Factors, Haplotype, Tumor necrosis factor-alpha, Tumor necrosis factor d4, Middle aged, Priority journal, Allele, Hla dqb1 antigen, Sequence analysis, Gene linkage disequilibrium, Middle Aged, Polymerase chain reaction, Hla, Regression Analysis, Tumor necrosis factor c1, Female, Regression analysis, Age distribution, Human, Tumor necrosis factor b7, Adult, Genotype, rheumatoid, Tumor necrosis factor, Tumor necrosis factor b4, Genetic predisposition to disease, Major clinical study, Colombia, Article, Genetic, Microsatellite repeats, Genetic susceptibility, Linkage disequilibrium, Humans, Genetic Predisposition to Disease, Tumor necrosis factor 308g, Rheumatoid arthritis, Polymorphism, Hla dr antigen, Microsatellites, Cytokine, Disease severity, Disease duration, Tumor necrosis factor 238g, Tumor necrosis factor a6, Genetic risk, Tumor necrosis factor a7, Tumor necrosis factor a8, Genetic polymorphism, Polymorphism, Genetic, Logistic regression analysis, Tumor necrosis factor alpha, Tumor Necrosis Factor-alpha, Arthritis, Confidence interval, Latin america, Gene frequency, Single nucleotide polymorphism, Severity of illness index, Clinical feature, Risk factors, Genetic association, Tumor necrosis factor e3, genetic, Controlled study, Microsatellite Repeats
Male, Unclassified drug, Protein function, Tnf, Hla antigen class 2, Gene sequence, Gene locus, Severity of Illness Index, Linkage Disequilibrium, Arthritis, Rheumatoid, Risk Factors, Haplotype, Tumor necrosis factor-alpha, Tumor necrosis factor d4, Middle aged, Priority journal, Allele, Hla dqb1 antigen, Sequence analysis, Gene linkage disequilibrium, Middle Aged, Polymerase chain reaction, Hla, Regression Analysis, Tumor necrosis factor c1, Female, Regression analysis, Age distribution, Human, Tumor necrosis factor b7, Adult, Genotype, rheumatoid, Tumor necrosis factor, Tumor necrosis factor b4, Genetic predisposition to disease, Major clinical study, Colombia, Article, Genetic, Microsatellite repeats, Genetic susceptibility, Linkage disequilibrium, Humans, Genetic Predisposition to Disease, Tumor necrosis factor 308g, Rheumatoid arthritis, Polymorphism, Hla dr antigen, Microsatellites, Cytokine, Disease severity, Disease duration, Tumor necrosis factor 238g, Tumor necrosis factor a6, Genetic risk, Tumor necrosis factor a7, Tumor necrosis factor a8, Genetic polymorphism, Polymorphism, Genetic, Logistic regression analysis, Tumor necrosis factor alpha, Tumor Necrosis Factor-alpha, Arthritis, Confidence interval, Latin america, Gene frequency, Single nucleotide polymorphism, Severity of illness index, Clinical feature, Risk factors, Genetic association, Tumor necrosis factor e3, genetic, Controlled study, Microsatellite Repeats
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