Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis.
Copyright policy )Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis.
Several studies have suggested that the presence of myeloid antigens is a poor prognostic factor in patients with acute lymphoid leukemia (ALL).We aimed to assess this possibility in Turkish patients.Seventy-three children with a diagnosis of ALL-L1 and 38 with ALL-L2 were included. Flow cytometry and fluorescein-isothiocynate conjugated antibodies were used to determined surface antigens on blasts.Myeloid antigens were positive in 48.4% with ALL-L1 and 60.5% with ALL-L2, the difference not being significant. Overall survival rates of myeloid antigen positive patients at 36, 60, and 72 months were 76%, 58%, and 48%, respectively, comparable to the corresponding 70%, 56%, and 46% in myeloid antigen negative patients (p >0.05).We did not find any association between myeloid antigen positivity and clinical and laboratory features of ALL.
- Cukurova University Turkey
Male, Adolescent, Antibodies, Monoclonal, Antigens, Differentiation, Myelomonocytic, Infant, Myeloid antigen, Acute lymphoblastic leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Flow Cytometry, Prognosis, Childhood, Immunophenotyping, Survival Rate, Child, Preschool, Antigens, Surface, Biomarkers, Tumor, Humans, Female, Child
Male, Adolescent, Antibodies, Monoclonal, Antigens, Differentiation, Myelomonocytic, Infant, Myeloid antigen, Acute lymphoblastic leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Flow Cytometry, Prognosis, Childhood, Immunophenotyping, Survival Rate, Child, Preschool, Antigens, Surface, Biomarkers, Tumor, Humans, Female, Child
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