Association between tumor size and immunohistochemical expression of Ki-67, p53 and BCL2 in a node-negative breast cancer population selected from a breast cancer screening program.
Copyright policy )Association between tumor size and immunohistochemical expression of Ki-67, p53 and BCL2 in a node-negative breast cancer population selected from a breast cancer screening program.
Breast cancer is the most common type of cancer among women. Breast infiltrating ductal carcinoma (IDC) is the most common type of breast cancer, approximately 80% of all breast carcinomas. The aim of this study was to analyze the association of tumor size, evaluated after histopathological analysis, with different clinical and biological parameters in IDC.The study group included 251 women with IDC without axillary lymph node involvement, aged between 27 and 81 years. Analyzed parameters were: age, histological grade, menopausal status, menarche, pregnancy, abortion, breastfeeding, contraceptive use, hormone replacement therapy, estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), Ki-67, p53 and BCL2.Pathological tumor size was between 0.2 and 5.1 cm (1.43±0.86 cm). Tumors in 45 cases exceeded 2 cm, in eight 3 cm and only in one 5 cm. Pathological size was significantly associated with age >70 vs. 70 years, histological grade 3 and immunohistochemically-augmented expression of Ki-67 and p53.
- University of Barcelona Spain
Adult, Receptor, ErbB-2, Breast Neoplasms, Càncer de mama, Immunoenzyme Techniques, Breast cancer, Pregnancy, Quimioteràpia, Biomarkers, Tumor, Chemotherapy, Humans, Early Detection of Cancer, Tumors, Aged, Aged, 80 and over, Middle Aged, Prognosis, Ki-67 Antigen, Proto-Oncogene Proteins c-bcl-2, Receptors, Androgen, Axilla, Female, Lymph Nodes, Neoplasm Grading, Follow-Up Studies
Adult, Receptor, ErbB-2, Breast Neoplasms, Càncer de mama, Immunoenzyme Techniques, Breast cancer, Pregnancy, Quimioteràpia, Biomarkers, Tumor, Chemotherapy, Humans, Early Detection of Cancer, Tumors, Aged, Aged, 80 and over, Middle Aged, Prognosis, Ki-67 Antigen, Proto-Oncogene Proteins c-bcl-2, Receptors, Androgen, Axilla, Female, Lymph Nodes, Neoplasm Grading, Follow-Up Studies
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).16 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!