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Молекулярная биологи...arrow_drop_down

Молекулярная биология

Article . 2010

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[Analysis of linkage and association of alleles of proinflammatory cytokines genes IL-6, IFNg and TNF with multiple sclerosis using transmission disequilibrium test (TDT)].

descriptionPublicationkeyboard_double_arrow_right Article 17 Dec 2010 Russian Journal:Molekuliarnaia biologiia, volume 44 (issn: 0026-8984,

Authors: O Iu, Makarycheva; E Iu, Tsareva; M A, Sudomoina; O G, Kulakova; O V, Bykova; N V, Gol'tsova; L M, Kuzenkova; +2 Authors

pmid: 21090238

[Analysis of linkage and association of alleles of proinflammatory cytokines genes IL-6, IFNg and TNF with multiple sclerosis using transmission disequilibrium test (TDT)].

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Abstract

Proinflammatory cytokines Interleukin-6 (IL-6), Interferon-gamma (IFNg) and Tumor necrosis factor (TNF) are known as participants of inflammation and play an important role in pathogenesis of multiple sclerosis (MS). Based on literature data about influence of SNPs G(-308)A of TNF gene, A(+874)T of IFNG gene and G(-174)C of IL-6 gene on production of these cytokines, we investigated association of these polymorphic sites with MS. Linkage and association of alleles of these genes with MS was analyzed by transmission disequilibrium test (TDT). In investigated group of 104 nuclear families of Russian ethnicity it was found that TNF* (-308)A allele transmitted from healthy heterozygous parents to affected children more frequently (p = 0.01). Linkage/association of IFNG and IL-6 alleles with MS was not revealed. Thus, data obtained indicate the participation of TNF gene in MS susceptibility in Russians.

Keywords

Adult, Male, Multiple Sclerosis, Adolescent, Interleukin-6, Tumor Necrosis Factor-alpha, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Russia, Interferon-gamma, Humans, Female, Genetic Predisposition to Disease, Child, Alleles

26 Research products, page 1 of 3

Interferon gamma
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Interleukin-6
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Interferon gamma
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Interleukin-6
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Interferon gamma
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cDNA FLJ52006, moderately similar to Interleukin-6
2017IsRelatedTo
Interferon gamma
2017IsRelatedTo
cDNA FLJ55231, highly similar to Interleukin-6
2017IsRelatedTo
Tumor necrosis factor
2017IsRelatedTo
Interferon gamma
2017IsRelatedTo

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