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Article . 2013

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[Pathogenesis of periodontal cell DNA damage during periodontitis].

descriptionPublicationkeyboard_double_arrow_right Article 31 Dec 2013 Russian Journal:Georgian medical news (issn: 1512-0112,

Authors: E V, Kuzenko; A N, Romaniuk; A M, Politun; R A, Moskalenko;

pmid: 23676490

[Pathogenesis of periodontal cell DNA damage during periodontitis].

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Abstract

Objective of our work: To carry out a comparative assessment of the expression level p53 protein and associate it with the degree of DNA damage in inflammation of periodontal disease. The research was conducted on periodontal tissue with signs of inflammation taken from dead patients of Sumy Regional Hospital. The materials were investigated using immunohistochemistry and DNA comet assay. It was established that acute inflammation in the periodontal tissues develop changes leading to DNA damage Acute inflammation is characterized by high levels of p53 Considerable damage to the nuclear DNA is called p53. p53 in apoptosis may include inability to repair.

Keywords

Adult, Inflammation, Male, Gingiva, Apoptosis, DNA, Middle Aged, Gene Expression Regulation, Humans, Female, Autopsy, Tumor Suppressor Protein p53, Periodontitis, Aged, DNA Damage

131 Research products, page 1 of 14

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