Association of XRCC3 gene rs861539 polymorphism with gastric cancer risk: evidence from a case-control study and a meta-analysis.
Copyright policy )Association of XRCC3 gene rs861539 polymorphism with gastric cancer risk: evidence from a case-control study and a meta-analysis.
The association between the X-ray repair cross-complementing group 3 (XRCC3) gene Thr241Met polymorphism (rs861539) and gastric cancer has been widely evaluated, but a definitive answer is so far lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. Although our case-control association study and the following meta analysis involving 6,520 subjects indicated null association of XRCC3 gene rs861539 polymorphism between gastric cancer patients and controls under both allelic (odds ratio (OR) = 1.02; 95% confidence interval (CI): 0.91-1.14; P = 0.739) and dominant (OR = 0.97; 95% CI: 0.78-1.21; P = 0.803) models. Stratified analysis by ethnicity demonstrated a significant association in Asians. We conclude that the XRCC3 gene rs861539 polymorphism was associated with the risk for gastric cancer in Asian populations.
- Shanghai Jiao Tong University China (People's Republic of)
- Ruijin Hospital China (People's Republic of)
- Shaoxing People's Hospital China (People's Republic of)
China, Chi-Square Distribution, Risk Assessment, DNA-Binding Proteins, Phenotype, Asian People, Gene Frequency, Risk Factors, Stomach Neoplasms, Case-Control Studies, Biomarkers, Tumor, Odds Ratio, Humans, Genetic Predisposition to Disease, Genetic Association Studies
China, Chi-Square Distribution, Risk Assessment, DNA-Binding Proteins, Phenotype, Asian People, Gene Frequency, Risk Factors, Stomach Neoplasms, Case-Control Studies, Biomarkers, Tumor, Odds Ratio, Humans, Genetic Predisposition to Disease, Genetic Association Studies
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