Powered by OpenAIRE graph
Found an issue? Give us feedback
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

[Molecular mechanisms of development and differentiation of eye structures in Drosophila and vertebrates].

Authors: V I, Mitashov; S, Koussulakos;

[Molecular mechanisms of development and differentiation of eye structures in Drosophila and vertebrates].

Abstract

The development of the eye is compared in Drosophila and vertebrates. Although the structure of the compound eye of invertebrates and of the cameral eye of vertebrates differs morphologically, there are striking similarities at the molecular level. Three groups of genes control morphogenesis of the eye: the genes responsible for eye rudiment formation, neurogenic genes, and proneural genes. In the eye rudiments of Drosophila and vertebrates, the homologous regulatory homeobox-containing genes ey/Pax6, so/Six3, rx/Rx, and optix/Optx2 are expressed. Transcription factors encoded by these conservative genes are involved in specific interactions with DNA. Another set of homologous genes, eya/Eya and dac/DACH/Dac, is also expressed during this developmental period. These genes encode nuclear transcription factors that are devoid of DNA-binding domains but are involved in the protein-protein interactions that control gene expression. Transcriptional complexes, which are products of homeobox-containing genes and nuclear factors, control morphogenesis of the eye in Drosophila and vertebrates. A similar set of homologous regulatory and nuclear genes controls morphogenesis during formation of ectopic eyes in Drosophila and vertebrates. Molecular biology approaches have allowed eye development to be examined at the level of developmental mechanisms. It has become evident that progress in understanding the mechanisms of eye development is due to studies carried out on Drosophila. Supporters of the idea of the polyphyletic origin of the compound and cameral eyes have noted significant differences in their structure and have failed to find distinct common features in their development. The hypothesis of the monophyletic origin of eyes has been substantiated by the results of molecular investigations.

Related Organizations
Keywords

Vertebrates, Morphogenesis, Animals, Gene Expression Regulation, Developmental, Drosophila, Eye

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Upload OA version
Are you the author? Do you have the OA version of this publication?