[Allelic polymorphism analysis of killer cell immunoglobulin-like receptor gene 3DL2 in Zhejiang Han population].
Copyright policy )[Allelic polymorphism analysis of killer cell immunoglobulin-like receptor gene 3DL2 in Zhejiang Han population].
To analyze the allelic polymorphism of killer cell immunoglobulin (Ig)-like receptor (KIR) gene 3DL2 in Zhejiang Han population.Allelic definition within KIR3DL2 was achieved through using the PCR-sequence specific oligonucleotide probes (PCR-SSOP) method and the specific amplification of exon 3-exon 4 and exon 8-exon 9. Twenty-one digoxigenin-labelled probes were used to the SSOP analysis.Seven alleles of KIR3DL2 were observed, in which KIR3DL2 *002 had the highest allele frequency, 0.57. One sample could not be given the allele combination according to the probe profile.The PCR-SSOP method was reliable. There is a distinctive allele frequency of KIR3DL2 in Zhejiang Han population.
- Blood Center of Zhejiang Province China (People's Republic of)
China, Genetics, Population, Polymorphism, Genetic, Asian People, Gene Frequency, Humans, Receptors, KIR3DL2, Sequence Analysis, DNA, Polymerase Chain Reaction
China, Genetics, Population, Polymorphism, Genetic, Asian People, Gene Frequency, Humans, Receptors, KIR3DL2, Sequence Analysis, DNA, Polymerase Chain Reaction
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