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Article . 2009

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[Plasma activated coagulation factor VII and Msp I polymorphism in elderly patients with coronary heart disease].

descriptionPublicationkeyboard_double_arrow_right Article 19 Mar 2009Journal:Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, volume 22 (issn: 1003-9406,

Authors: Qing-hua, Lu; Yi-meng, Du; Zhao-qiang, Dong; Fang-hong, Lu; Pei-e, Wen; Ke-zhi, Wang; Qi, Tian; +2 Authors

pmid: 16331575

[Plasma activated coagulation factor VII and Msp I polymorphism in elderly patients with coronary heart disease].

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Abstract

To investigate the association of activated coagulation factor VII(F7a) and its gene Msp I polymorphism with coronary heart disease in elderly patients.This was a case-control study, and the method of candidate gene was adopted. F7 genotypes were identified with polymerase chain reaction amplified genomic deoxyribonulieic acid (DNA) and Msp I restriction fragment length polymorphism analysis, and the level of plasma F7a was detected with recombinant tissue factor method for 108 elderly patients with coronary heart disease and 120 sex- and age-matched healthy control subjects.(1) Plasma F7a levels was significantly higher in elderly patients with coronary heart disease than in healthy control subjects (2.88 +/- 0.62 vs 2.58 +/- 0.60 microg/L, P 0.05). (3) F7a level was significantly higher in RR genotype than in Q allele carriers (2.72 +/- 0.60 vs 1.98 +/- 0.59 microg/L, P < 0.05) and was associated with F7 gene polymorphism.Plasma F7a level may be an independent risk factor of coronary heart disease in elderly patients, and it may be influenced by the Msp I polymorphism of F7 gene.

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Shandong Women’s University
China (People's Republic of)

Keywords

Male, Binding Sites, Polymorphism, Genetic, Genotype, Coronary Disease, Factor VII, Middle Aged, Polymerase Chain Reaction, Deoxyribonuclease HpaII, Gene Frequency, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Polymorphism, Restriction Fragment Length, Aged

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