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Article . 2011

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[The expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma].

descriptionPublicationkeyboard_double_arrow_right Article 06 Jun 2011Journal:Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, volume 19

Authors: Binquan, Wang; Haili, Zhang; Yanqiu, Chen;

pmid: 16124648

[The expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma].

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Abstract

To study the expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma (LSCC).Western-blot analysis was performed on tumor core,transition core, "tumor-free" core of 20 specimens of fresh LSCC by using anti-eIF4E and VEGF antiserums.The expression of eIF4E protein level from "tumor-free" core, transition core and tumor core of LSCC appeared progressive overexpression. It appeared that there was significant elevation of VEGF protein level in tumor core compared with tumor transition and "tumor-free" core. There appeared to be statistically significantly correlation of eIF4E and VEGF expression.Overexpression of eIF4E may be a molecular marker of malignant transformation and progression. The overexpression of VEGF is highly associated with the growth and metastasis of LSCC, and may be of prognostic value. The correlation of eIF4E and VEGF may serve as a potential target for antiangiogenic therapy of LSCC.

Related Organizations

First Hospital of Shanxi Medical University
China (People's Republic of)

Keywords

Vascular Endothelial Growth Factor A, Eukaryotic Initiation Factor-4E, Carcinoma, Squamous Cell, Humans, Prognosis, Laryngeal Neoplasms

16 Research products, page 1 of 2

Eukaryotic translation initiation factor 4E
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Vascular endothelial growth factor A165
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Vascular endothelial growth factor variant
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Eukaryotic translation initiation factor 4E
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Vascular endothelial growth factor A121
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Vascular endothelial growth factor, isoform CRA_d
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Eukaryotic translation initiation factor 4E isoform A
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Eukaryotic translation initiation factor 4E
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VEGFA protein
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Vascular endothelial growth factor
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