Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig.
Copyright policy )Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig.
The G protein coupled serotonin (5-HT) receptors, with seven membrane spanning domains, form a multigene family of which several members have been cloned and sequenced. The presence of 5-HT1D binding sites to our knowledge has not yet been reported in mouse. Here we describe the cloning and sequencing by the polymerase chain reaction (PCR) method of two 5-HT1D receptor sequences of the third cytoplasmic loop in mouse, strongly suggesting the existence of two 5-HT1D receptor genes, located on chromosome 4. A homologous sequence to one of them was cloned in guinea pig.
- Institut Pasteur France
Blotting, Southern, Mice, Base Sequence, Receptors, Serotonin, Guinea Pigs, Molecular Sequence Data, Animals, Cloning, Molecular, Polymerase Chain Reaction
Blotting, Southern, Mice, Base Sequence, Receptors, Serotonin, Guinea Pigs, Molecular Sequence Data, Animals, Cloning, Molecular, Polymerase Chain Reaction
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