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International Journal of Clinical Pharmacology and Therapeutics

Article . 1997

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Treatment of left ventricular hypertrophy in hypertensive patients with a combination of verapamil and captopril--a multicenter study.

descriptionPublicationkeyboard_double_arrow_right Article 18 Nov 1997 English Journal:International journal of clinical pharmacology and therapeutics, volume 35 (issn: 0946-1965,

Authors: D, Magometschnigg; D, Brandt; R, Hofmann; K, Sihorsch; K, Stoschitzky; M, Zangeneh; G, Zenker;

pmid: 9314093

Treatment of left ventricular hypertrophy in hypertensive patients with a combination of verapamil and captopril--a multicenter study.

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Abstract

The regression of left ventricular hypertrophy in hypertensive patients was evaluated in a multicenter study with a combination therapy of verapamil 120 mg and captopril 25 mg given once or twice daily. The degree of left ventricular hypertrophy was assessed using echocardiography, while hypertension was evaluated by means of twice daily blood pressure self-measurements and ambulatory blood pressure monitoring.An overall of 61 patients was evaluated. Left ventricular mass had decreased by 13.5% during the 6-month treatment period. This reduction neither correlated with the baseline left ventricular mass nor with the extent of blood pressure decrease.The combination therapy-verapamil 120 mg plus captopril 25 mg--is well tolerated by hypertensive patients with left ventricular hypertrophy and produced a decrease of left ventricular mass that is independent of the extent of blood pressure decrease.

Keywords

Adult, Male, Captopril, Myocardium, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Middle Aged, Calcium Channel Blockers, Electrocardiography, Verapamil, Heart Rate, Hypertension, Humans, Drug Therapy, Combination, Female, Hypertrophy, Left Ventricular, Antihypertensive Agents

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