Growth factor independence 1 (Gfi1) as a regulator of p53 activity and a new therapeutical target for ALL.
Copyright policy Growth factor independence 1 (Gfi1) as a regulator of p53 activity and a new therapeutical target for ALL.
The transcriptional repressor Gfi1 can be a so-called "oncorequisite" factor that is required for the development and maintenance of lymphoid neoplasia, such as Acute Lymphoblastic Leukemia (ALL), but does not have a direct role in the ontogeny of the disease. The study supporting this role of Gfi1 (Khandanpour C, Phelan J, et al., Cancer Cell, 2013, 23:200-214) shows that inhibition of Gfi1 cannot only cure mice from ALL but also blocks the expansion of human primary ALL cells. The study concludes that this feature of Gfi1 can be exploited to improve current ALL therapies.
- Essen University Hospital Germany
Histone Demethylases, Mice, Knockout, Models, Genetic, Gene Expression Regulation, Leukemic, Apoptosis, Mice, SCID, Oligonucleotides, Antisense, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Xenograft Model Antitumor Assays, Morpholinos, DNA-Binding Proteins, Mice, Mice, Inbred NOD, Animals, Humans, Tumor Suppressor Protein p53, Cell Proliferation, DNA Damage, Interleukin Receptor Common gamma Subunit, Transcription Factors
Histone Demethylases, Mice, Knockout, Models, Genetic, Gene Expression Regulation, Leukemic, Apoptosis, Mice, SCID, Oligonucleotides, Antisense, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Xenograft Model Antitumor Assays, Morpholinos, DNA-Binding Proteins, Mice, Mice, Inbred NOD, Animals, Humans, Tumor Suppressor Protein p53, Cell Proliferation, DNA Damage, Interleukin Receptor Common gamma Subunit, Transcription Factors
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