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Biochemical and Biophysical Research Communications

Article . 1992

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Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).

descriptionPublicationkeyboard_double_arrow_right Article 26 Oct 1992 English Journal:Biochemical and biophysical research communications, volume 187 (issn: 0006-291X,

Authors: L, Xiao; P, Celano; A R, Mank; C, Griffin; E W, Jabs; A L, Hawkins; R A, Casero;

pmid: 1417826

Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).

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Abstract

The super induction of spermidine/spermine N1-acetyltransferase (SSAT), has been implicated in the cytotoxic response of human solid tumors to the bis(ethyl)polyamines. The SSAT response is a phenotype specific response and is modulated at the level of increased steady-state mRNA levels and enzyme protein. The human genomic region (4,095 bases) containing the coding sequence of SSAT has been cloned and localized to the Xp22.1 region. Primer extension analysis indicates the transcription of SSAT starts 179 bases upstream from the translational start site and appears to be under the control of a "TATA-less" promoter. The availability of this human clone will facilitate the direct functional examination of the SSAT gene.

Related Organizations

Johns Hopkins Medicine
United States

Keywords

X Chromosome, Base Sequence, Transcription, Genetic, RNA Splicing, Molecular Sequence Data, Restriction Mapping, Chromosome Mapping, Regulatory Sequences, Nucleic Acid, Introns, Genes, Oligodeoxyribonucleotides, Acetyltransferases, Humans, RNA, Messenger, Cloning, Molecular, Promoter Regions, Genetic

3 Research products, page 1 of 1

H.sapiens gene for spermidine/spermine N1-acetyltransferase
2018IsRelatedTo
Diamine acetyltransferase 1
2017IsRelatedTo
Homo sapiens (human) hypothetical protein
2018IsRelatedTo

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