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Article . 2011

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Growth hormone-releasing hormone stimulates the secretion of interleukin 17 from human peripheral blood mononuclear cells in vitro.

descriptionPublicationkeyboard_double_arrow_right Article 16 Mar 2011 English Journal:Neuro endocrinology letters, volume 31 (issn: 0172-780X,

Authors: Tomasz, Stepien; Hanna, Lawnicka; Jan, Komorowski; Henryk, Stepien; Agnieszka, Siejka;

pmid: 21196925

Growth hormone-releasing hormone stimulates the secretion of interleukin 17 from human peripheral blood mononuclear cells in vitro.

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Abstract

Growth hormone-releasing hormone (GHRH) plays a crucial role in the secretion of GH from the pituitary, acts as a growth factor in variety of cancer cells and possesses immunomodulatory activity. Interleukin(IL)-17 apart from its pro-inflammatory role has been also shown to play a role in carcinogenesis. The effect of GHRH on the IL-17 has not been studied so far.To evaluate the effect of GHRH on the secretion of IL-17 from human peripheral blood mononuclear cells (PBMC) in vitro.The concentrations of IL-17 in supernatants from PBMC cultured for 24 hrs were assessed using ELISA kit.We show for the first time that GHRH can stimulate the secretion of IL-17 from human PBMC in 24 hrs culture, and that GHRH antagonist counteracts this effect.Our study further elucidates the immunomodulatory role of GHRH.

Related Organizations

Copernicus Memorial Hospital
Poland

Keywords

Interleukin-17, Leukocytes, Mononuclear, Humans, Enzyme-Linked Immunosorbent Assay, Growth Hormone-Releasing Hormone, Cells, Cultured

5 Research products, page 1 of 1

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