[The establishment of the MPEL for carboxylic acid derivatives in the air of a work area by using mathematical models].

A I, Gurova; N Ia, Smoliar; N A, Drozhzhina

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Article . 1992

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[The establishment of the MPEL for carboxylic acid derivatives in the air of a work area by using mathematical models].

descriptionPublicationkeyboard_double_arrow_right Article 17 Dec 1992 Russian Journal:Gigiena truda i professional'nye zabolevaniia (issn: 0016-9919,

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Authors: A I, Gurova; N Ia, Smoliar; N A, Drozhzhina;

pmid: 1427353

[The establishment of the MPEL for carboxylic acid derivatives in the air of a work area by using mathematical models].

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Abstract

Reports of MACs for carboxylic acid derivatives as sodium methoxyacetate (SMOA), methyl chlorpropionate (MCP) and acetoacetic ether (AAE). SMOA shows low toxicity, no cumulation and specific action MCP demonstrates moderate toxicity, low cumulation no specific action in concentrations close to Limac. AAE presents toxicity low in oral usage and moderate when inhaled, low cumulation, no irritation and sensitization. Tentative safe level of injury and MAC estimated for the aforesaid substances together with toxicity parameters compared with the substances studied before allowed the authors to set the MAC of SMOA--10, MCP--2, AAE--10 mg/m3.

Keywords

Dose-Response Relationship, Drug, Guinea Pigs, Carboxylic Acids, Air Pollutants, Occupational, Acetates, Models, Biological, Acetoacetates, Rats, Lethal Dose 50, Mice, Hydrocarbons, Chlorinated, Animals, Maximum Allowable Concentration, Propionates, Mathematics

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