Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.
Copyright policy )Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.
Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor.Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 104 with deep vein thrombosis and 98 control subjects.Only 3/112 (3%) patients with portal vein thrombosis had factor V Leiden, compared to 1/98 (1%) controls and 16/104 (15%) with deep vein thrombosis; of these, 3, 1 and 15, respectively, were heterozygous for this mutation.Factor V Leiden contributes little, if at all, to the development of portal vein thrombosis in southern India.
Adult, Male, Heterozygote, Adolescent, Portal Vein, Homozygote, Factor V, India, Infant, Middle Aged, Mesenteric Veins, Splenic Vein, Child, Preschool, Humans, Female, Genetic Predisposition to Disease, Child, Polymorphism, Restriction Fragment Length, Activated Protein C Resistance, Aged
Adult, Male, Heterozygote, Adolescent, Portal Vein, Homozygote, Factor V, India, Infant, Middle Aged, Mesenteric Veins, Splenic Vein, Child, Preschool, Humans, Female, Genetic Predisposition to Disease, Child, Polymorphism, Restriction Fragment Length, Activated Protein C Resistance, Aged
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