[Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma].
Copyright policy )[Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma].
To investigate the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in patients with gastric carcinoma in different stages.The expressions of HB-EGF protein and mRNA in normal gastric tissues, metaplasic intestinal mucosa, early-stage gastric cancer and advanced-stage gastric cancer tissues were detected by immunohistochemistry and in situ hybridization.HB-EGF expression was only detected in the parietal cells of the gastric fundic glands and in gastrin cells of the pyloric glands in normal gastric tissues. Weak HB-EGF expression was detected in the epithelial cells of the gastric mucosa in intestinal metaplasic mucosa, and the expression increased in all layers of the gastric mucosa in early-stage gastric cancer. Intense HB-EGF expression was observed in advanced gastric cancer.Increased HB-EGF expression may be implicated in the pathogenesis and development of gastric carcinoma.
- Second Peoples Hospital of Shaanxi Province China (People's Republic of)
Adult, Male, Adenocarcinoma, Middle Aged, Gastric Mucosa, Stomach Neoplasms, Tumor Cells, Cultured, Humans, Intercellular Signaling Peptides and Proteins, Female, RNA, Messenger, Aged, Heparin-binding EGF-like Growth Factor
Adult, Male, Adenocarcinoma, Middle Aged, Gastric Mucosa, Stomach Neoplasms, Tumor Cells, Cultured, Humans, Intercellular Signaling Peptides and Proteins, Female, RNA, Messenger, Aged, Heparin-binding EGF-like Growth Factor
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