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Investigative Ophthalmology & Visual Science

Article . 1987

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Genetic regulation of light damage to photoreceptors.

descriptionPublicationkeyboard_double_arrow_right Article 04 Aug 1987 English Journal:Investigative ophthalmology & visual science, volume 28 (issn: 0146-0404,

Authors: M M, LaVail; G M, Gorrin; M A, Repaci; L A, Thomas; H M, Ginsberg;

pmid: 3596986

Genetic regulation of light damage to photoreceptors.

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Abstract

Albino mice of different inbred strains have been exposed to constant fluorescent lighting at an illuminance level of 115-130 ft-c for intervals of 1-6 weeks. Under these conditions the photoreceptors in retinas of albino BALB/cByJ mice rapidly degenerate, whereas the photoreceptors in retinas of albino C57BL/6J-c2J mice are remarkably more resistant to light damage. F1 heterozygotes produced from these two strains display an intermediate degree of light-induced degeneration. These findings demonstrate that phenotypically identical populations with different genetic constitutions can show markedly different sensitivities to light, and that genetic factors must now be included as a determinant for the severity of light damage.

Keywords

Male, Heterozygote, Mice, Inbred BALB C, Light, Retinal Degeneration, Retina, Rats, Mice, Inbred C57BL, Mice, Radiation Injuries, Experimental, Phenotype, Genes, Regulator, Animals, Female, Photoreceptor Cells

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	135
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%