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Cancer Research

Article . 1995

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Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

descriptionPublicationkeyboard_double_arrow_right Article 15 Dec 1995 English Journal:Cancer research, volume 55 (issn: 0008-5472,

Authors: S M, Hewitt; S, Hamada; T J, McDonnell; F J, Rauscher; G F, Saunders;

pmid: 7585606

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

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Abstract

The Wilms' tumor gene WT1 functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors. The bcl-2 and c-myc proto-oncogenes are essential for regulation of apoptosis and cell proliferation with roles in development and oncogenesis. We found that WT1 can repress transcription of both the bcl-2 and c-myc promoters. This suggests that WT1 regulates bcl-2 and c-myc during renal development, and the loss of functional WT1 results in deregulation of bcl-2 and c-myc, contributing to tumor formation.

Related Organizations

The University of Texas MD Anderson Cancer Center
United States

Keywords

Base Sequence, Molecular Sequence Data, Genes, myc, Wilms Tumor, Kidney Neoplasms, DNA-Binding Proteins, Gene Expression Regulation, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins, Proto-Oncogenes, Humans, Genes, Tumor Suppressor, Amino Acid Sequence, Promoter Regions, Genetic, WT1 Proteins, Transcription Factors

19 Research products, page 1 of 2

Wilms tumor protein homolog
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Myc proto-oncogene protein
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Wilms tumor protein homolog
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Apoptosis regulator Bcl-2
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B-cell leukemia/lymphoma 2, isoform CRA_a
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Wilms' tumor mRNA
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Truncated Wilms' tumor protein
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Wilms tumor protein homolog
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	184
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