[Prolonged administration of antidepressants induces changes in the pulsed release but not in the reverse uptake of biogenic amines].
Copyright policy )[Prolonged administration of antidepressants induces changes in the pulsed release but not in the reverse uptake of biogenic amines].
The experiments on rats have shown that antidepressant concentrations that cause 50% inhibition of 14C-NA and 3H-HT uptake by brain slices remain unchanged following prolonged administration of antidepressants (imipramine, pirazidole, harmane and its derivatives--C-153, C-307, C-394, C-395), as compared to the control. Electrical stimulation of brain slices upon long-term treatment of rats with antidepressants and preincubation with 14C-NA and 3H-HT enhanced presynaptic release of radioactive mark at concentrations of antidepressants (EC2) 3-14 times lower than those in the control animals. Long-term antidepressant administration reduces the inhibitory influence of clonidine and HT on presynaptic release of 14C-NA and 3H-HT by brain slices. It is suggested that long-term administration of antidepressants decreases the sensitivity of terminal axons of NA- and HT-ergic neurons to autoinhibitory effect of neurotransmitter release.
Neurons, Biogenic Amines, Norepinephrine, Serotonin, Time Factors, Animals, Brain, Antidepressive Agents, Rats
Neurons, Biogenic Amines, Norepinephrine, Serotonin, Time Factors, Animals, Brain, Antidepressive Agents, Rats
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