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Zhurnal nevrologii i psikhiatrii im S S Korsakova

Article . 2014

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[Clinical and genetic markers of chronic cerebral ischemia].

Name: [Clinical and genetic markers of chronic cerebral ischemia].
Keywords: Adult, Genetic Markers, Male, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Middle Aged, Neuropsychological Tests, Intracranial Arteriosclerosis, Brain Ischemia

descriptionPublicationkeyboard_double_arrow_right Article 19 Dec 2014 Russian Journal:Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, volume 114 (issn: 1997-7298,

Authors: I V, Zvereva; M G, Aksenova; E V, Krikova; I E, Serdiuk; S G, Burd;

pmid: 25042484

[Clinical and genetic markers of chronic cerebral ischemia].

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Abstract

To study the effectiveness of common neuropsychological tests for the verification of the diagnosis of cerebral ischemia (CE) and a role of polymorphisms in SERT, ApoE and BDNF genes in its development.We studied 272 inpatients, aged from 37 to 70 years, with CE of the first stage (58 patients), CE of the second stage (121 patients) and CE of the third stage (93 patients). A set of neuropsychological tests, as well as biochemical and molecular-genetic studies were performed.Reitan test was the most effective test for the diagnosis of cognitive impairment. The results of the Clock Drawing Test and MMSE were correlated with the disease severity but did not distinguish between the first and second stages of CE. Arterial hypertension and stenosing atherosclerosis of brain vessels were significant predictors of CE. SERT gene was a marker of the CE risk in men. The genotype SS was associated with the risk of CE with early age-at-onset. No association of ApoE and BDNF genes with CE was found.

Keywords

Adult, Genetic Markers, Male, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Middle Aged, Neuropsychological Tests, Intracranial Arteriosclerosis, Brain Ischemia, Apolipoproteins E, Sex Factors, Chronic Disease, Hypertension, Humans, Female, Aged

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Fields of Science

medical and health sciences

clinical medicine

Fields of Science

medical and health sciences

clinical medicine

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