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Haematologica

Article . 2006

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Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia.

descriptionPublicationkeyboard_double_arrow_right Article 27 Sep 2006 English Journal:Haematologica, volume 91 (issn: 1592-8721,

Authors: Irina, Costea; Albert, Moghrabi; Caroline, Laverdiere; Alexandru, Graziani; Maja, Krajinovic;

pmid: 16870553

Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia.

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Abstract

The gene polymorphisms of the methotrexate (MTX) action pathway influence event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL). Here we assessed whether the gene variants associated with lower EFS also correlate with lower rates of episodes of toxicity. Homozygous individuals for cyclin D1 (CCND1) A870 allele and carriers of at least one methylenetetrahydrofolate reductase (MTHFR) T677 variant had a significantly lower frequency of weeks with high-grade hematologic and liver toxicity during consolidation and maintenance treatment, as based on the analysis of 186 pediatric ALL patients. This finding may have importance for MTX dose adjustment.

Keywords

Polymorphism, Genetic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Hematologic Diseases, Disease-Free Survival, Folic Acid, Methotrexate, Liver, Folic Acid Antagonists, Humans, Child, Methylenetetrahydrofolate Reductase (NADPH2)

14 Research products, page 1 of 2

MTHF reductase
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Cyclin D1
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Cyclin D1
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Methylenetetrahydrofolate reductase short isoform
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Methylenetetrahydrofolate reductase intermediate form
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Cyclin N-terminal domain-containing protein
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G1/S-specific cyclin-D1
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Methylenetetrahydrofolate reductase
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Methylenetetrahydrofolate reductase
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Methylenetetrahydrofolate reductase
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