Ischemic reperfusion modeling of damage parenchyma of pancreas with development of acute pancreatitis is performed in experiment on 8 outbred dogs. The influence assessment of ischemic reperfusion factor on gland fabric is carried out. Application of alprostadil preparation for intraarterial infusional therapy is offered at pancreatonecrosis on the basis of obtained experimental data. Efficiency of application at patients with pancreatonecrosis of regionar intraarterial infusion prostacyclin for microcirculation «unblocking» is analyzed at pancreatonecrosis.