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Structural changes in submandibular salivary gland, caused by heavy metal salts, and their correction with Dialipon (experimental study)

Authors: Boiko, Volodymyr Oleksandrovych; Tkach, Hennadii Fedorovych; Kiptenko, Liudmyla Ivanivna; Lyndin, Mykola Serhiiovych;

Structural changes in submandibular salivary gland, caused by heavy metal salts, and their correction with Dialipon (experimental study)

Abstract

Целью исследования явилось установление возможностей коррекции структурных изменений в поднижнечелюстной слюнной железе препаратом диалипон, которые вызваны вредным воздействием солей тяжелых металлов на организм крыс разных возрастных периодов. Структурные изменения и их коррекция были изучены на гистологических препаратах, окрашенных гематоксилин- эозином, Ван Гизону, шик-реакцией, которые исследовали и фотографировали с помощью цифровой системы вывода изображения «SEO Scan». По сравнению с результатами гистологического исследования ткани поднижнечелюстной слюнной железы животных без коррекции под влиянием микроэлементоза у животных, получавших диалипон, отмечается большая сохранность железистого эпителия, меньшая распространенность дистрофических и дисциркуляторных изменений, процессов склеротизации в строме. При сравнении восстановительных возможностей диалипона установлено, что у животных разных возрастных групп оказывается различная эффективность действия корректора. У крыс молодого и зрелого возраста происходит полное восстановление структурных изменений. У крыс старческого возраста оказываются более низкие репаративные возможности, восстановление структуры менее полное и эффективное, чем у животных младших возрастных групп. Setting of possibilities of structural changes correction in submandibular salivary gland with a Dialipone drug, caused by adverse effect of heavy metals salts on an organisms of different age group rats. Structural changes and their correction were studied on the histological preparations basis painted by hematoxyhematoxylin-eozin, Van-Gizon, PAS reaction, investigated and photographed by means of the digital image display system "SEO Scan". In comparison to the results of submandibular salivary gland tissue histological research of animals without any correction of microelementosis, animals that took Dialipone are marked with a better glandular epithelium saving, less widespreading of dystrophic and dyscirculatory changes, sclerotization processes in stroma. When comparing of Dialipone restoration possibilities, it was set, that different age group animals show different application efficiency of the corrector. The rats of young and mature age have more complete renewal of structural changes. The rats of advanced age show worse reparative capabilities, less complete and effective renewal of structural changes.

Country
Ukraine
Related Organizations
Keywords

корректор, слюнная железа, salivary gland, коректор, тяжелые металлы, heavy metals, слинні залози, corrector, важкі метали

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green