The purpose of this study is to offer a systematic, unified approach to the Mellin-Barnes integrals and associated special functions as Fox H, Aleph ℵ, and Saxena I function, encompassing the fundamental features and important conclusions under natural minimal assumptions on the functions in question. The approach’s pillars are the concept of a Mellin-Barnes integral and the Mellin representation of the given function. A Sinc quadrature is used in conjunction with a Sinc approximation of the function to achieve the numerical approximation of the Mellin-Barnes integral. The method converges exponentially and can handle endpoint singularities. We give numerical representations of the Aleph ℵ and Saxena I functions for the first time.