Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome
Copyright policy )Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome
Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB1∗0602, was detected in significant quantities in patients with KLS (three of 12, p=0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.
- Cathay General Hospital Taiwan
- Taipei Medical University Hospital Taiwan
- National Defense Medical Center Taiwan
- Taipei Medical University Taiwan
- Fu Jen Catholic University Taiwan
Male, Adolescent, Genotype, Taiwan, Kleine-Levin Syndrome, Polymerase Chain Reaction, Young Adult, HLA-DQ beta-Chains, Humans, Female, Genetic Predisposition to Disease, Child, Alleles
Male, Adolescent, Genotype, Taiwan, Kleine-Levin Syndrome, Polymerase Chain Reaction, Young Adult, HLA-DQ beta-Chains, Humans, Female, Genetic Predisposition to Disease, Child, Alleles
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!