Diagnostic Parameters in Liquid-Based Cervical Cytology Using a Coagulant Suspension Fixative
Copyright policy )Diagnostic Parameters in Liquid-Based Cervical Cytology Using a Coagulant Suspension Fixative
To evaluate in detail the morphology of cervical cell samples suspended in the coagulant fixative BoonFix (Finetec, Tokyo, Japan) in liquid-based Papspin slides (Thermo Shandon, Pittsburgh, Pennsylvania, U.S.A) to detect shifts in diagnostic parameters for infections and neoplasia.Split samples of 1,010 cases were collected. All Papspin slides were scanned with neural network technology. In 849 cases the diagnosis was "within normal limits"; in 22 cases it was preneoplasia. In 151 special cases conventional smears were compared with thin-layer slides.In 85% of the 151 special cases, a shift of the diagnostic parameter was observed in the Papspin slide. The parameter adhesion of inflammatory cells to epithelial cells was easier to discern in 94% of the cases, and adhesion of microorganisms varied 43-100%. Koilocytosis was more visible in 79%. Prominent nucleoli in atypical and malignant cells were enhanced in 50-100% of cases with preneoplasia. The fact that the cells on the Papspin slide were no longer present in diagnostic streaks posed a problem only in the case of follicular cervicitis.The shifts in parameters facilitated the diagnostic process. BoonFix permits the screening of liquid-based Papspin slides, which have proven to be well suited to automated neural network scanning.
- University of Groningen Netherlands
mass screening, THIN-LAYER, Tissue Fixation, cervical cancer, Uterine Cervical Neoplasms, Cervix Uteri, Infections, neural networks (computer), Pattern Recognition, Automated, Fixatives, Predictive Value of Tests, Humans, Mass Screening, liquid-based cytology, Vaginal Smears, SLIDES, BoonFix (R), LESIONS, Protozoan Infections, P-16INK4A, Carcinoma, Reproducibility of Results, Epithelial Cells, Papspin (R), Bacterial Infections, PERFORMANCE, CANCER, PAP TEST, SPECIMENS, Mycoses, TESTS, CELLS, Female, Neural Networks, Computer, Precancerous Conditions
mass screening, THIN-LAYER, Tissue Fixation, cervical cancer, Uterine Cervical Neoplasms, Cervix Uteri, Infections, neural networks (computer), Pattern Recognition, Automated, Fixatives, Predictive Value of Tests, Humans, Mass Screening, liquid-based cytology, Vaginal Smears, SLIDES, BoonFix (R), LESIONS, Protozoan Infections, P-16INK4A, Carcinoma, Reproducibility of Results, Epithelial Cells, Papspin (R), Bacterial Infections, PERFORMANCE, CANCER, PAP TEST, SPECIMENS, Mycoses, TESTS, CELLS, Female, Neural Networks, Computer, Precancerous Conditions
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).12 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!