Heme oxygenase 1 variations and lung function decline in smokers: proof of replication

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2008 Netherlands English Publisher:BMJJournal:Journal of Medical Genetics, volume 45, pages 400-400 (issn: 0022-2593, eissn: 1468-6244,

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Authors: Siedlinski, M.; van Diemen, C. C.; Postma, D. S.; Boezen, H. M.;

doi: 10.1136/jmg.2008.058123

pmid: 18519631

handle: 11370/1ecc6218-6e7a-4ac7-aed6-337d92d1a85d

Heme oxygenase 1 variations and lung function decline in smokers: proof of replication

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Abstract

We provide supportive evidence for a role of the promoter polymorphism (GT-repeat) in heme oxygenase 1 (HO-1) in relation to lung function loss over time. This observation has been made by Guenegou and colleagues in a Caucasian population, and a call for replication of these results in a larger and independent cohort was made.1 The relevance of HO-1 has been widely acknowledged.2 Chronic obstructive pulmonary disease (COPD)—often a consequence of abnormally accelerated lung function decline3—has been widely studied in relation to HO-1 promoter GT-repeat, using a …

Country

Netherlands

Related Organizations

University of Groningen
Netherlands
University Medical Center Groningen
Netherlands

Keywords

Adult, Male, Polymorphism, Genetic, Genotype, Smoking, Reproducibility of Results, MICROSATELLITE POLYMORPHISM, SUSCEPTIBILITY, Middle Aged, OBSTRUCTIVE PULMONARY-DISEASE, Forced Expiratory Volume, Humans, Female, HEME OXYGENASE-1, Lung, POPULATION, Heme Oxygenase-1, OXYGENASE-1 GENE PROMOTER, Aged

15 Research products, page 1 of 2

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