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Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Dec 2022 United Kingdom English Publisher:American Society for Cell Biology (ASCB)Journal:Molecular Biology of the Cell, volume 33 (issn: 1059-1524, eissn: 1939-4586,

Authors: Ishii, M; Ludzia, P; Marcianò, G; Allen, W; Nerusheva, OO; Akiyoshi, B;

doi: 10.1091/mbc.e22-07-0269-t

pmid: 36129769

pmc: PMC9727816

handle: 20.500.11820/b78b3351-3304-4271-9ba4-af84c9a863b8

Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei

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Abstract

Little is known about the mechanism of kinetochore assembly in evolutionarily divergent eukaryotes called kinetoplastids, which have a unique set of kinetochore proteins. In this study, the authors have characterized two homologous kinetoplastid kinetochore proteins (KKT2 and KKT3) and identified their interaction partners.

Country

United Kingdom

Related Organizations

University of North Carolina at Chapel Hill
United States
University of Edinburgh
United Kingdom
University of Oxford
United Kingdom

Keywords

Chromosome Segregation, Trypanosoma brucei brucei, Centromere, Protozoan Proteins, Cell Cycle Proteins, Articles, Kinetochores

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