Separation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells.
Copyright policy )Separation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells.
Using a Ficoll velocity sedimentation gradient, we have been able to fractionate concanavalin A (Con A)-induced helper and suppressor cells into separate pools. Cells activated by Con A to mediate helper activity are Ly1+, do not require DNA synthesis for induction, and remain as small cells after activation. Suppressor cells are Ly23+, are found in the blast cell fraction and their induction is not inhibitable by prior treatment with mitomycin C or irradiation, both of which inhibit DNA synthesis. The implications of such findings are discussed.
- Jackson Laboratory United States
- University of California, San Diego United States
Immunosuppression Therapy, Unknown:, T-Lymphocytes, Genes:, Cell Separation, DNA, Lymphocyte Activation, Radiation:, Mitomycins, Mice, Phenotype, Strains:, Tissue Culture:, Concanavalin A, Animals, Cobalt Radioisotopes, Serology:
Immunosuppression Therapy, Unknown:, T-Lymphocytes, Genes:, Cell Separation, DNA, Lymphocyte Activation, Radiation:, Mitomycins, Mice, Phenotype, Strains:, Tissue Culture:, Concanavalin A, Animals, Cobalt Radioisotopes, Serology:
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