A Comparison among the Growth Hormone-Lowering Effects in Acromegaly of the Somatostatin Analog SMS 201-995, Bromocriptine, and the Combination of Both Drugs
Copyright policy )A Comparison among the Growth Hormone-Lowering Effects in Acromegaly of the Somatostatin Analog SMS 201-995, Bromocriptine, and the Combination of Both Drugs
The acute GH inhibitory effects of 50 micrograms SMS 201-995, a somatostatin analog, and 2.5 mg bromocriptine were compared in 17 acromegalic patients. SMS 201-995 suppressed plasma GH levels after 2-6 h to 5 micrograms/liter or less in 10 of these 17 patients, while bromocriptine did the same in only 5 of them. There was much variation in the responsiveness to both drugs in these patients, but the GH-lowering effect of 50 micrograms SMS 201-995 was significantly greater than that of 2.5 mg bromocriptine. SMS 201-995 and bromocriptine together significantly suppressed plasma GH levels in 2 of 3 acromegalic patients who were insensitive to both compounds when tested separately. We conclude that most acromegalic patients respond better to SMS 201-995, while a few patients are more sensitive to the GH-lowering effect of bromocriptine. In addition, the combination of SMS 201-995 and bromocriptine can be of value in a few acromegalic patients who do not respond to either drug alone.
Adult, Male, Injections, Subcutaneous, Administration, Oral, Middle Aged, Octreotide, Growth Hormone, Acromegaly, Humans, Drug Therapy, Combination, Female, Somatostatin, Bromocriptine
Adult, Male, Injections, Subcutaneous, Administration, Oral, Middle Aged, Octreotide, Growth Hormone, Acromegaly, Humans, Drug Therapy, Combination, Female, Somatostatin, Bromocriptine
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