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Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Sep 2021 English Publisher:Elsevier BVJournal:Journal of Clinical Virology Plus, volume 1, page 100,029 (issn: 2667-0380,

Authors: Peter C.W. Yip; Peter K.C. Cheng; Edman T.K. Lam; Alan K.L. Tsang; Gannon C.K. Mak; Ken H.L. Ng; Dominic N.C. Tsang; +1 Authors

doi: 10.1016/j.jcvp.2021.100029

pmid: 35262015

pmc: PMC8200330

Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong

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Abstract

Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong.Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases.SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays. Preliminary positive cases were further tested by whole genome sequencing.From Dec 2020 to May 2021, 55 SARS-CoV-2 cases belonged to lineage B.1.351. Among them, eight genomes were clustered together, all of them were local cases with epidemiological link.To track variants of SARS-CoV-2 and to allow early implementation of control measures, SARS-CoV-2 genomic surveillance must be consistently performed.

Related Organizations

Centre for Health Protection
Hong Kong
Department of Health
China (People's Republic of)

Keywords

Lineage B.1.351, SARS-CoV-2, Whole genome sequencing, COVID-19, Hong Kong, Community acquired, Infectious and parasitic diseases, RC109-216, Article

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