The expression of PCNA, c-erbB-2, p53, ER and PR as well as atypical hyperplasia in tissues nearby the breast cancer
Copyright policy )The expression of PCNA, c-erbB-2, p53, ER and PR as well as atypical hyperplasia in tissues nearby the breast cancer
To examine the proper margin for breast conservative surgery in Chinese women population. 40 breast cancer specimens were collected and each sample was dissected into several groups: primary tumor group, 1 cm paracarcinoma, 2 cm paracarcinoma, 3 cm paracarcinoma and excessive 3 cm paracarcinoma groups. The immunohistochemistry staining was performed to measure the expression levels of proliferating cell nuclear antigen (PCNA), c-erbB-2, p53, estrogen receptor (ER) and progesterone receptor (PR). The gene expressions of PCNA, c-erbB-2, and p53 gradually decreased with the increased distance from primary tumor (P 0.05) showed higher risk factors (c-erbB-2, p53) than the 3 cm and excessive 3 cm paracarcinoma groups (P 0.05). Beyond the paracarcinoma 2 cm distance, the tissues showed significant decreases in tumor gene expression, which could represent the appropriate region for breast conservative surgery.
- Xi’an Jiaotong-Liverpool University China (People's Republic of)
Adult, Hyperplasia, Receptor, ErbB-2, Age Factors, Gene Expression, Breast Neoplasms, Middle Aged, Immunohistochemistry, Receptors, Estrogen, Proliferating Cell Nuclear Antigen, Axilla, Biomarkers, Tumor, Humans, Female, Lymph Nodes, Tumor Suppressor Protein p53, Receptors, Progesterone
Adult, Hyperplasia, Receptor, ErbB-2, Age Factors, Gene Expression, Breast Neoplasms, Middle Aged, Immunohistochemistry, Receptors, Estrogen, Proliferating Cell Nuclear Antigen, Axilla, Biomarkers, Tumor, Humans, Female, Lymph Nodes, Tumor Suppressor Protein p53, Receptors, Progesterone
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