The 32‐base pair deletion of the chemokine receptor 5 gene (CCR5‐Δ32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
Copyright policy )The 32‐base pair deletion of the chemokine receptor 5 gene (CCR5‐Δ32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
AbstractCCR5 is a chemokine receptor expressed on T‐cells and macrophages. A 32‐base pair deletion in the chemokine receptor 5 gene (CCR5‐Δ32) leads to a non‐functional receptor. Conflicting evidence exists whether this deletion is associated with primary sclerosing cholangitis (PSC). We genotyped the CCR5‐Δ32 variant in 363 PSC patients and 366 controls. No significant increase in the Δ32 allele frequency was detected in the PSC patients compared to controls (12.7% vs 10.7% OR = 1.22, 95% CI [0.88, 1.68], P = 0.23). Survival analysis did not reveal any significant effects from CCR5‐Δ32 genotypes on disease progression. Thus, in this study (power > 90%, given OR = 2, α = 0.05), we were unable to replicate previous findings and our results do not support an involvement of CCR5‐Δ32 in either PSC susceptibility or progression.
- University of Oslo Norway
- Institute of Immunology Croatia
- Karolinska University Hospital Sweden
Male, Receptors, CCR5, Cholangitis, Sclerosing, Scandinavian and Nordic Countries, Gene Frequency, Case-Control Studies, Confidence Intervals, Disease Progression, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Base Pairing, Alleles, Gene Deletion
Male, Receptors, CCR5, Cholangitis, Sclerosing, Scandinavian and Nordic Countries, Gene Frequency, Case-Control Studies, Confidence Intervals, Disease Progression, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Base Pairing, Alleles, Gene Deletion
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