Acrolein genotoxicity in Drosophila melanogaster. I. Somatic and germinal mutagenesis under proficient repair conditions

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1991 English Publisher:Elsevier BVJournal:Mutation Research/Genetic Toxicology, volume 260, pages 247-256 (issn: 0165-1218,

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Authors: L M, Sierra; A R, Barros; M, García; J A, Ferreiro; M A, Comendador;

doi: 10.1016/0165-1218(91)90033-i

pmid: 1908054

Acrolein genotoxicity in Drosophila melanogaster. I. Somatic and germinal mutagenesis under proficient repair conditions

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Abstract

The genotoxicity of acrolein in D. melanogaster was investigated using 2 different SMART assays, the eye spot and wing spot tests, and 2 germinal tests, the sex-linked recessive lethal (SLRLT) and sex chromosome loss (SCLT) tests. For the 2 latter, exposure by feeding as well as injection was used. The results indicate that: (i) acrolein is mutagenic in the SLRLT when injected but not when fed; (ii) the SCLT did not reveal clastogenic effects; (iii) acrolein had genotoxic effects in both SMART assays; (iv) we also had several indications that acrolein is metabolized into a second genotoxic product.

Related Organizations

University of Oviedo
Spain

Keywords

Drosophila melanogaster, Sex Chromosomes, Mutagenesis, Mutagenicity Tests, Animals, Genes, Lethal, Genes, Recessive, Acrolein, Mutagens

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