Effects of cannabinoids in Krox-24 targeted mice
Copyright policy )Effects of cannabinoids in Krox-24 targeted mice
Krox-24 is an immediate early gene encoding a zinc-finger transcription factor implicated in several adaptive responses, and its induction by cannabinoids has been reported. We used mice targeted in the Krox-24 gene to specifically dissect the role of this protein in the acute and chronic central actions of cannabinoids. We report here on the ability of cannabinoids to activate G-proteins and to inhibit adenylyl cyclase, and to elicit behavioral responses in wild-type and mutant mice. The behavioral parameters and the biochemical correlates of abstinence after delta9-THC withdrawal were evaluated. We show that Krox-24 is not involved in the acute analgesic effects of delta9-THC and in the SR precipitated delta9-THC withdrawal syndrome.
Male, Mice, Knockout, Marijuana Abuse, Behavior, Animal, Cannabinoids, Receptors, Drug, Binding, Competitive, Immediate-Early Proteins, DNA-Binding Proteins, Mice, GTP-Binding Proteins, Cerebellum, Cyclic AMP, Animals, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Receptors, Cannabinoid, Spleen, Adenylyl Cyclases, Early Growth Response Protein 1
Male, Mice, Knockout, Marijuana Abuse, Behavior, Animal, Cannabinoids, Receptors, Drug, Binding, Competitive, Immediate-Early Proteins, DNA-Binding Proteins, Mice, GTP-Binding Proteins, Cerebellum, Cyclic AMP, Animals, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Receptors, Cannabinoid, Spleen, Adenylyl Cyclases, Early Growth Response Protein 1
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