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Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2002 English Publisher:American Physiological SocietyJournal:American Journal of Physiology-Endocrinology and Metabolism, volume 282, pages E721-E732 (issn: 0193-1849, eissn: 1522-1555,

Authors: Peter J. Wookey; Christopher S. Kovacs; Mandy L. Woodland; Kirsten R. McDonald; Linda L. Chafe; Neva J. Fudge;

doi: 10.1152/ajpendo.00369.2001

pmid: 11832378

Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange

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Abstract

The expression of calcitropic genes and proteins was localized within murine placenta during late gestation (the time frame of active calcium transfer) with an analysis of several gene-deletion mouse models by immunohistochemistry and in situ hybridization. Parathyroid hormone-related protein (PTHrP), the PTH/PTHrP receptor, calcium receptor, calbindin-D9k, Ca2+-ATPase, and vitamin D receptor were all highly expressed in a localized structure of the murine placenta, the intraplacental yolk sac, compared with trophoblasts. In the PTHrP gene-deleted or Pthrp-null placenta in which placental calcium transfer is decreased, calbindin-D9kexpression was downregulated in the intraplacental yolk sac but not in the trophoblasts. These observations indicated that the intraplacental yolk sac contains calcium transfer and calcium-sensing capability and that it is a probable route of maternal-fetal calcium exchange in the mouse.

Related Organizations

University of Melbourne
Australia
Memorial University of Newfoundland
Canada

Keywords

Calcitonin, Mice, Knockout, Calbindins, Placenta, Calcium-Binding Proteins, Parathyroid Hormone-Related Protein, Gene Expression, Biological Transport, Gestational Age, Calcium-Transporting ATPases, Placental Lactogen, Immunohistochemistry, Mice, Animals, Intercellular Signaling Peptides and Proteins, Calcium, Female, Maternal-Fetal Exchange, In Situ Hybridization, Glycoproteins

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