Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Copyright policy )Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition.
- Tohoku University Japan
- Osaka University Japan
- Asahi University Japan
Lipopolysaccharides, Male, Immunology, Gram-Positive Bacteria, Nocardia, Mice, Cell Wall, Gram-Negative Bacteria, Escherichia coli, Immunology and Allergy, Animals, Drosophila Proteins, Mice, Knockout, Antigens, Bacterial, Membrane Glycoproteins, Corynebacterium diphtheriae, NF-kappa B, Mice, Inbred C57BL, Infectious Diseases, Interleukin-1 Receptor-Associated Kinases, Lipid A, Macrophages, Peritoneal, Female
Lipopolysaccharides, Male, Immunology, Gram-Positive Bacteria, Nocardia, Mice, Cell Wall, Gram-Negative Bacteria, Escherichia coli, Immunology and Allergy, Animals, Drosophila Proteins, Mice, Knockout, Antigens, Bacterial, Membrane Glycoproteins, Corynebacterium diphtheriae, NF-kappa B, Mice, Inbred C57BL, Infectious Diseases, Interleukin-1 Receptor-Associated Kinases, Lipid A, Macrophages, Peritoneal, Female
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