
Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling.
peptide hormone, Intestinal function, aggression, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, locomotion, Aggression, intestinal function, Neuropeptide, Endocrinology, neuropeptide, Locomotion, feeding
peptide hormone, Intestinal function, aggression, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, locomotion, Aggression, intestinal function, Neuropeptide, Endocrinology, neuropeptide, Locomotion, feeding
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