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Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling

Authors: Dick R. Nässel; Michael Williams;

Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling

Abstract

Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling.

Keywords

peptide hormone, Intestinal function, aggression, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, locomotion, Aggression, intestinal function, Neuropeptide, Endocrinology, neuropeptide, Locomotion, feeding

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
33
Top 10%
Average
Top 10%
Green
gold