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Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

descriptionPublicationkeyboard_double_arrow_right Article 17 Dec 1999 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 286, pages 2,328-2,331 (issn: 0036-8075, eissn: 1095-9203,

Authors: Kenneth S. Korach; Vickie R. Walker; Madhabananda Sar; S. Curtis Hewitt; John F. Couse; Donna O. Bunch; B. J. Davis;

doi: 10.1126/science.286.5448.2328

pmid: 10600740

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

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Abstract

Mice lacking estrogen receptors α and β were generated to clarify the roles of each receptor in the physiology of estrogen target tissues. Both sexes of αβ estrogen receptor knockout (αβERKO) mutants exhibit normal reproductive tract development but are infertile. Ovaries of adult αβERKO females exhibit follicle transdifferentiation to structures resembling seminiferous tubules of the testis, including Sertoli-like cells and expression of Müllerian inhibiting substance, sulfated glycoprotein-2, andSox9. Therefore, loss of both receptors leads to an ovarian phenotype that is distinct from that of the individual ERKO mutants, which indicates that both receptors are required for the maintenance of germ and somatic cells in the postnatal ovary.

Related Organizations

University of North Carolina at Chapel Hill
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National Institutes of Health
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National Institute of Health
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Research Triangle Park Foundation
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Experimental Pathology Laboratories
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Keywords

Anti-Mullerian Hormone, Male, Mice, Knockout, Estradiol, Ovary, Disorders of Sex Development, Estrogen Receptor alpha, High Mobility Group Proteins, Cell Differentiation, Luteinizing Hormone, Growth Inhibitors, Mice, Clusterin, Receptors, Estrogen, Gene Targeting, Animals, Estrogen Receptor beta, Female, Glycoproteins, Molecular Chaperones

12 Research products, page 1 of 2

Estrogen receptor beta
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Estrogen receptor
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Estrogen receptor
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Estrogen receptor
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C-terminally truncated estrogen receptor alpha product-2b
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Estrogen receptor beta
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Estrogen receptor beta
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C-terminally truncated estrogen receptor alpha product-1
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N-terminally truncated estrogen receptor alpha product-2c
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C-terminally truncated estrogen receptor alpha product-3
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